Application of 134227-45-5, The chemical industry reduces the impact on the environment during synthesis 134227-45-5, name is 3,4,5-Trifluorobenzonitrile, I believe this compound will play a more active role in future production and life.
Step A: Preparation of 4-[(l,3-Dimethyl-lH-pyrazol-5-yl)oxy]-3 ,5 -difluorobenzonitrile Potassium carbonate (1.38 g, 10 mmol) was added to a solution of 2,4-dihydro-2,5-dimethyl-3H-pyrazol-3-one (0.70 g, 6.3 mmol) in N,Lambda/-dimethylformamide (15 mL).3,4,5-Trifluorobenzonitrile (0.94 g, 6.0 mmol) was added, and the reaction mixture was heated at 75 0C under a nitrogen atmosphere for 16 h, then allowed to cool. The reaction mixture was partitioned between water (60 mL) and ethyl acetate (30 mL). The organic phase was washed with water (2 x 30 mL) and brine (30 mL), dried over MgSOphi and concentrated to give the title compound as a yellow oil (1.38 g).1H NMR delta 7.36 (m, 2H), 5.24 (s, IH), 3.78 (s, 3H), 2.16 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5-Trifluorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; LONG, Jeffrey, Keith; HONG, Wonpyo; TAGGI, Andrew, Edmund; WO2010/101973; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts