Adding a certain compound to certain chemical reactions, such as: 19924-43-7, name is 2-(3-Methoxyphenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19924-43-7, Recommanded Product: 19924-43-7
Step A: Preparation of 2-(3-methoxyphenyl)-2-methylpropanenitrile:; To a stirred solution of 2-(3-methoxyphenyl)acetonitrile (6.2g, 42.1mmol), 40% aq tetrabutylammonium hydroxide (5.1g, 7.8mmol) and 50% aq NaOH (3Og, 375mmol) in toluene (30ml) was added CH3I (8ml, 129mmol) at room temperature. The reaction mixture was stirred for 16 hours, CH3I (4ml) was further added and the reaction mixture was stirred for another 5 hours at room temperature. The reaction mixture was diluted with EtOAc and washed with water and brine. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a short silica gel column (hex: methylene chloride, 2:1) to give the title compound.1H NMR (400 MHz, d-DMSO): 1.74 (s, 6H); 3.8 (s, 3H); 6.9-7.04 (m, 2H); 7.11 (t, IH); 7.29-7.31 (m, IH).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3-Methoxyphenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; WELLSTAT THERAPEUTICS CORPORATION; WO2009/151695; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts