Application of 327-74-2, The chemical industry reduces the impact on the environment during synthesis 327-74-2, name is 2-Amino-5-cyanobenzotrifluoride, I believe this compound will play a more active role in future production and life.
General procedure: A solution of NaHCO3 (0.82 g) in distilledwater (4 mL) was stirred for 10 minutes and to it was added DCM (4 mL) followedby the different aniline 6-9, 11(2.4 mmol). The reaction mixture was cooled to 0 C, thiophosgene (0.3 mL, 3.7mmol) was added dropwise over 10 minutes and the reaction was then stirred atr.t. o.n. The mixture was then diluted with DCM (20 mL), washed with brine (20mL), the organic layer was dried over Na2SO4 andconcentrated to dryness.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-5-cyanobenzotrifluoride, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ferla, Salvatore; Bassetto, Marcella; Pertusati, Fabrizio; Kandil, Sahar; Westwell, Andrew D.; Brancale, Andrea; McGuigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3636 – 3640;,
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