In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 610-66-2, name is 2-(2-Nitrophenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-(2-Nitrophenyl)acetonitrile
In a 1000ml three-necked round bottom flask equipped with a mechanical stirrer, thermometer and condenser, add 2-nitrophenylacetonitrile (32g, 0.2mol), 2-chloro-4,6-dimethoxy-1,3 5-Triazine (53 g, 0.3 mol), N, N-dimethylformamide (400 mL), stirred for 10 minutes, after the reaction material is dissolved, potassium carbonate (41 g, 0.3 mol) is added, and then the temperature is raised to 90 degrees to react 24 hours.After monitoring the reaction, the system was naturally cooled to room temperature, and the next oxidation operation was directly performed. Under mechanical agitation, 30% hydrogen peroxide (91 g, 0.8 mol) was slowly added dropwise to the system cooled down to room temperature to control the system temperature not to exceed 70 degrees.After the dropwise addition, the mixture was stirred at room temperature for 10 hours. Pour into 500mL of water and stir, the solid is precipitated and filtered directly,Wash the filter cake with a small amount of water to obtain 40 g of solid product (4,6-dimethoxy-1,3,5-triazin-2-yl) (2-nitrophenyl) methanoneThe yield is 70%.
The synthetic route of 610-66-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Anhui Chemical Institute; Luo Hongwen; Zhang Jiaxing; Xu Shouming; Mei Liyun; Fan Zhen; (11 pag.)CN110981825; (2020); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts