Adding a certain compound to certain chemical reactions, such as: 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 40497-11-8, COA of Formula: C7H8N2O2
Example 11 Preparation of 5-aminopyrazole (VII) [0071] To 2,6-dichloro-4-trifluoromethyl aniline 230 g and acetic acid 150 ml was added 1.1 m of nitrosyl sulphuric acid over one hour at 30 C. and maintained at 30 C. for one more hour. Heat the mass to 50-55 C. over ½ hour and the absence of 2,6-dichloro-4-trifluoromethyl aniline was monitored. Cool the mass to 30 C., and the excess nitrosyl sulphuric acid was destroyed. [0072] The above diazotized mass was added to a mixture of 250 ml of acetic acid, 162 g ethyl-2,3-dicyanoproprionate and 425 ml water over 4-5 hours maintaining temperature 0-5 C. Further maintained at 0 C./2 hours, 5 C./1 hour, 10 C./1 hour, 15 C./1 hour. 800 ml water was added at 15 C. over ½ hour, extracted the solution with 3×250 ml methylene dichloride. Layers were separated. Dichloromethane layer was washed with 250 ml water, cooled the dichloromethane layer to 0 C. and washed with 250 ml 8N aq. NH3 under stirring for one hour. Layers were separated, dichloromethane layer was taken and NH3 gas was passed at 0-5 C. till free NH3 was observed on top of the condenser and maintained the reaction mass for 3-4 hours at 0-5 C. Then 250 ml water was added, stirred for ½ hour, layers were separated, extracted aq. layer with 2×100 ml dichloromethane, dichloromethane layer was dried with MgS04, dichloromethane layer was concentrated to dryness, to obtain 288 g of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethyl phenyl)-pyrazole of 98% purity.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2,3-dicyanopropanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Gharda, Keki Hormusji; US2013/30190; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts