Related Products of 939-79-7, These common heterocyclic compound, 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a stirred solution of 18(166.51 mmol), 23 (166.51 mmol) or 27 (166.51 mmol) in CCl4 (350 mL) were added NBS (199.82 mmol) and benzoyl peroxide (16.65 mmol) under nitrogen atmosphere. The mixture was heated at reflux temperature for 13 h and then cooled to room temperature. The reaction mixture was filtered and then washed with CH2Cl2 (2 × 400 mL). The combined organic layers waswashed with water (200 mL), dried over anhydrous Na2SO4, and then evaporated to dryness under reduce pressure. The residue was purified by MPLC on silica gel to afford the titled compounds.
The synthetic route of 939-79-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jin, Cheng Hua; Krishnaiah, Maddeboina; Sreenu, Domalapally; Subrahmanyam, Vura Bala; Park, Hyun-Ju; Park, So-Jung; Sheen, Yhun Yhong; Kim, Dae-Kee; Bioorganic and Medicinal Chemistry; vol. 22; 9; (2014); p. 2724 – 2732;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts