Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 123-06-8, name is Ethoxymethylenemalononitrile, A new synthetic method of this compound is introduced below., Computed Properties of C6H6N2O
Step 1 (0885) [00206] To a mixture of EpsilonbetaNu (1.39 ml_, 10 mmol) and cyclohexylhydrazine hydrochloride (1.51 g, 10 mmol) in EtOH (35 ml_) was added ethoxymethylenemalononitrile (1.22 g, 10 mmol) portion wise. The reaction mixture was heated at reflux for 5 hours, then cooled to room temperature and concentrated in vacuo. The residue was taken up in EtOAc (50 ml_) and washed with water (2 chi 25 ml_). The organic phase was dried over MgSCU, filtered and concentrated in vacuo to return 5-amino-1-cyclohexyl-pyrazole-4-carbonitrile (1.95 g, 103%) as an orange solid which was used without further purification. 1 H NMR (300 MHz, CDC ) delta 7.49 (s, 1 H), 4.45 (s, 2H), 3.77 (tt, J = 1 1.2, 4.2 Hz, 1 H), 1.88 (ddt, J = 17.4, 1 1.4, 5.4 Hz, 6H), 1.83-1.65 (m, 1 H), 1.49-1.32 (m, 1 H), 1.38-1.15 (m, 2H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JORDAN, Allan; NEWTON, Rebecca; (174 pag.)WO2017/178844; (2017); A1;,
Nitrile – Wikipedia,
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