Reference of 2338-75-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2338-75-2, name is 4-(Trifluoromethyl)phenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows.
Intermediate (51 .1 ) tert-butyl 4-(cyano(4- (trifluoromethyl)phenyl)methylene)piperidine- 1 -carboxylateTo the solution of 4-(trifluoromethyl)phenylacetonitrile (2560.9 mg; 1 3.83 mmol; 1 .06 eq.) in ethanol (50 mL), 21 % sodium ethoxide (5.70 ml; 15.27 mmol; 1 .17 eq.) in ethanol was added dropwise at RT. After stirred for 30 min, a solution of 1 -boc-4- piperidone (2600.00 mg; 13.05 mmol; 1 .00 eq.) in ethanol (10 mL) was added slowly. The reaction mixture was stirred at room teperature for 4h. The reaction was quenched with 50mL of saturated aqueous NH4CI and concentrated to half volume. The aqueous solution was extracted with ether three times. The combined organic extracts were washed with brine, dried and then concentrated to give the crude product, which was purified by Biotage chromatography with EtOAc/Hexane (5-30%) to yield the desired product as light yellow solid (3200.00 mg, yield 66.9%).
The chemical industry reduces the impact on the environment during synthesis 4-(Trifluoromethyl)phenylacetonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK PATENT GMBH; LAN, Rouxi; HUCK, Bayard R.; CHEN, Xiaoling; DESELM, Lizbeth Celeste; XIAO, Yufang; QIU, Hui; NEAGU, Constantin; MOCHALKIN, Igor; JOHNSON, Theresa L.; WO2013/40044; (2013); A1;,
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