Related Products of 368-77-4, The chemical industry reduces the impact on the environment during synthesis 368-77-4, name is 3-(Trifluoromethyl)benzonitrile, I believe this compound will play a more active role in future production and life.
General procedure: General Procedure for Preparation of Tetrazoles in Water(Method II). TBAHS (0.25 mmol) was added to a mixture of nitrile (1 mmol), sodium azide (1.5 mmol), and 2 mL H2O in around-bottomed flask. The reaction mixture was heated to 85 C. After completion of the reaction (as monitored by TLC), the crude reaction mixture was transferred into a separatory funnel, to which was added 1 N HCl (15 mL) extracted by ethylacetate (EtOAc, 10 mL × 5). The combined organic layers were washed with H2O and dried over anhydrous sodium sulfate, and were evaporated under reduced pressure to give pure 5-substituted-1H-tetrazole.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Wang, Zengtao; Liu, Zhiguo; Cheon, Seung Hoon; Bulletin of the Korean Chemical Society; vol. 36; 1; (2015); p. 198 – 202;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts