Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 876-31-3, name is 4-(Cyanomethyl)benzonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 4-(Cyanomethyl)benzonitrile
General procedure: To a solution of alpha,beta-unsaturated ketones 3 (0.30 mmol) in CH2Cl2 (0.6 mL) at room temperature was added pyrrolidine (0.060 mmol) followed by addition of 2-arylacetate or 2-arylacetonitrile 2 (0.45 mmol). The resulting solution was stirred at room temperature until complete consumption of alpha,beta-unsaturated ketones 3 was observed as determined by TLC. The resulting mixture was direct purified by silica gel chromatography to afford desired compounds 4 and 5.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Do, Jungho; Kim, Sung-Gon; Tetrahedron Letters; vol. 52; 18; (2011); p. 2353 – 2355;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts