Electric Literature of 32446-66-5,Some common heterocyclic compound, 32446-66-5, name is 4,4′-Dicyanobenzophenone, molecular formula is C15H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound III-2 (3.51 g, 8 mmol) was dissolved in 50 mL of dry THF and stirred.Cooled to -20 C in a nitrogen atmosphere,Then, 1.6 M of n-BuLi n-hexane solution (5 mL, 8 mmol) was slowly added dropwise with a syringe, and after the addition was completed,The reaction mixture was stirred at this temperature for an additional 1 hour.A solution of V-2 (1.86 g, 8 mmol) dissolved in 5 mL of dry THF was slowly added dropwise with a syringe.After the dropwise addition was completed, the reaction mixture was stirred at the same temperature for half an hour, and then warmed to room temperature and stirred for 1 hour.Finally, it was stirred under reflux overnight. The reaction mixture was carefully poured into 300 mL of ice water and stirred.The extract was extracted with 50 mL of EtOAc (3 mL).The desiccant was removed by suction filtration, and the filtrate was evaporated to dryness on a rotary evaporator.Compound VI-2 is obtained
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,4′-Dicyanobenzophenone, its application will become more common.
Reference:
Patent; Tianjin Xiaoxin Pharmaceutical Technology Co., Ltd.; Zeng Huaxian; (7 pag.)CN108129370; (2018); A;,
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