Extracurricular laboratory: Synthetic route of

Electric Literature of 22364-68-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22364-68-7 name is 2-(o-Tolyl)acetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 5; Preparation of(Z)-2-(2-Methyl-phenyl)-3-(1H-pyrrol-2-yl)acryIonitrile Under High PressureA thick walled tube was charged with 1 H-pyrrole-2-carbaldehyde (2.0 g, 21.0 mmol), 2-methylphenyIacetonitrile (2.5 g, 18.9 mmol, 0.9 equivalents), ethanol (75 ml), and 40% aqueous Triton B (4.0 ml, 3.3 mmol). The tube was EPO sealed and heated to 90 0C for 4 days. Removal of the solvent, followed by chromatography on silica gel using dichloromethane/petroleum spirits (20:80) as eluant afforded a yellow solid (1.2 g). This is Compound 16 in Table 8.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(o-Tolyl)acetonitrile, and friends who are interested can also refer to it.

Reference:
Patent; SCHERING-PLOUGH LTD.; WO2006/55565; (2006); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts