Electric Literature of 17626-40-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17626-40-3 as follows.
Step 1 : 1 H-Benzo[dlimidazole-5-carbonitrile3,4-Diaminobenzonitrile (5.0 g; 37 mmol) was dissolved in 5 N HCI (200 ml). After addition of formic acid (20 ml) the mixture was heated to reflux for 3 h. After cooling to room temperature, the mixture was basified by means of aqueous NH3-solution and put into a fridge. The precipitated solid was collected by filtration, washed with water and used without further purification. Yield: 3.6 g (67.6%) MS m/z: 144.2 [M+H]+
According to the analysis of related databases, 17626-40-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PROBIODRUG AG; HEISER, Ulrich; RAMSBECK, Daniel; HOFFMANN, Torsten; BOEHME, Livia; DEMUTH, Hans-Ulrich; WO2011/107530; (2011); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts