Electric Literature of 72291-30-6, The chemical industry reduces the impact on the environment during synthesis 72291-30-6, name is Methyl 2-cyano-2-methylpropanoate, I believe this compound will play a more active role in future production and life.
A mixture of cyano-dimethyl-acetic acid methyl ester (5 g, 39.4 mmol), Boc anhydride (17.2 g, 78.7 mmol), and NiCl2 (0.51 g, 3.94 mmol) in MeOH (200 mL) was cooled in an ice bath. NaBH4 (10.4 g, 276 mmol) was slowly added over 1 h at 0C, and the resulting mixture was stirred at r.t. for 16 h. Diethylenetriamine (4.3 mL, 39.4 mmol) was then added, and the mixture was stirred for 30 min. The solvent was evaporated, and the residue was partitioned between EtOAc (200 mL) and saturated NaHCC>3 (400 mL). The aqueous layer was extracted with additional EtOAc, and the organic layers were combined, dried over MgSO/t, and concentrated. The crude product was purified by column chromatography (0-40% EtOAc/hexanes) to give 2.5 g of the title compound as a clear oil. H NMR (CDCI3, 200 MHz): 8ppm= 4.95 (br s, 1H), 3.69 (s, 3H), 3.24 (d, 2H, J= 6.6 Hz), 1.44 (s, 9H), 1.20 (s, 6H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-cyano-2-methylpropanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.; WO2013/134660; (2013); A1;,
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