Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, A new synthetic method of this compound is introduced below., SDS of cas: 1080-74-6
A solution of intermediate 2 (112 mg, 0.12 mmol) and INCN(170 mg, 0.88 mmol, 7.2 eq) in tert-butanol (25 mL) was degassedbefore addition of triethylamine (2e3 drops, catalytic amount) andsubsequent refluxed under N2 atmosphere for 6 h. After cooling toroom temperature, the reaction was quenched by water andextracted with chloroform (CHCl3). The organic layer was washedby water for several times. Column chromatography on silica gelwith CHCl3:hexane (1:1) as the eluent afforded IFTIC as darkredsolid (180 mg, 53%), mp 223.3-224.6 C. 1H NMR (CDCl3, 500 MHz)delta (ppm): 8.92 (s, 2H), 8.72 (d, 2H, J 7.4 Hz), 7.98 (d, 2H, J 6.9 Hz),7.92 (d, 2H, J 3.5 Hz), 7.88-7.75 (m, 12H), 7.69 (s, 2H), 7.62 (d, 2H,J 3.5 Hz), 2.13-2.10 (m, 8H), 1.17-1.02 (m, 40H), 0.76 (t, 12H,J 7.0 Hz), 0.72-0.65 (m, 8H)13C NMR (CDCl3, 125 MHz) delta (ppm):188.5,161.6,160.6,152.5, 151.2,146.5,143.7,140.6,140.1,138.2,137.0,136.2, 135.2, 134.6, 131.7, 126.0, 125.4, 124.9, 123.8, 122.4, 120.8,120.5, 114.6, 69.7, 55.2, 40.5, 31.8, 29.9, 29.2, 29.1, 23.8, 22.6, 14.0.Anal. calcd for C86H90N4O2S2 (%): C 80.96, H 7.11, N 4.39; found (%):C 80.91, H 7.09, N 4.38.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zhang, Jie; Zhao, Baofeng; Mi, Yuhua; Liu, Hongli; Guo, Zhaoqi; Bie, Guojun; Wei, Wei; Gao, Chao; An, Zhongwei; Dyes and Pigments; vol. 140; (2017); p. 261 – 268;,
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