Related Products of 368-77-4,Some common heterocyclic compound, 368-77-4, name is 3-(Trifluoromethyl)benzonitrile, molecular formula is C8H4F3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under the protection of nitrogen,To a 10 ml Schlek reaction tube (a glass apparatus commonly used in anhydrous anaerobic operation), 1.0 mmol of o-bromobenzyl alcohol, 1.3 mmol of 3-trifluoromethylbenzonitrile,0.1mmol RuH2(PPh3)4,0.1 mmol palladium acetate,0.15 mmol 1,3-bis (2,6-diisopropylphenyl) -4,5-dihydro-imidazole tetrafluoroborate,0.15mmol silver oxide,4.0mmol sodium hydride,And 5 ml of N,N-dimethylformamide,Replace the reaction tube three times with nitrogen,Then heated to 160 C with an oil bath under magnetic stirring.The reaction was refluxed for 20 hours.Remove the oil bath and lower it to room temperature;Add 3 ml of water to the reaction solution.Use 5ml of dichloromethaneAlkane extraction three times,The organic phases were combined and dried over anhydrous MgSO4 for 30 min.Filtered; the filtrate was concentrated with a rotary evaporator, the concentrated solids with dichloromethane as solvent, the product was recrystallized to give pure 11, 80% yield.
The synthetic route of 368-77-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Lianyungang Duxiang Chemical Co., Ltd.; Xu Chen; Wang Duzheng; Xie Jianxin; Wang Chuanmin; Zheng Xiaobin; (9 pag.)CN108586342; (2018); A;,
Nitrile – Wikipedia,
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