Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Fluoro-3-nitrobenzonitrile
(a) 4-Fluoro-3-nitro-benzylamine hydrochlorideBH3/THF (120 mL; 120 mmol) was added to a solution of 4-fluoro-3-nitro-benzonitrile (10 g; 60 mmol) in THF (50 mL) over 30 min at 0 °C and the resulting mixture was stirred at 0 °C for 1 h and at rt for 3 h. The mixture was acidified to pH ~1 and stirred for 1 h at rt, basicified to pH -7-8 and extracted with EtOAc. The organic layer was dried over Na2S04, filtered and concentrated. The residue was dissolved in Et20 and treated with a solution of HCI in 1 ,4- dioxane to give the sub-title compound.Yield: 8.7 g (70percent).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; PRIEPKE, Henning; KUELZER, Raimund; MACK, Juergen; PFAU, Roland; STENKAMP, Dirk; PELCMAN, Benjamin; ROENN, Robert; LUBRIKS, Dimitrijs; SUNA, Edgars; WO2012/76672; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts