Reference of 185147-08-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 185147-08-4, name is 4-Fluoro-3-methylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 5a 10430] Under nitrogen atmophere, sodium hydride (60percent suspension in mineral oil, 32 mg, 0.804 mmol) is added to example 4a (120 mg, 0.402 mmol) and 4-fluoro-3-methyl- benzonitrile (109 mg, 0.804 mmol) in dry 1 ,4-dioxane (2 mE) cooled to 00 C. and stirring is continued for 3 hat it. Volatiles are evaporated under reduced pressure to furnish a residue that is purified by preparative HPEC (stationary phase: Sun- fire C18 ODE 5 tm 19x 100 mm. Mobile phase: ACN/H20+ CF3COOH 0.05percent). Fractions containing the title compound are combined, acetonitrile is evaporated under reduced pressure, the aqueous layer is basified with sat. NaHCO3 and extracted with DCM. The organic layer is dried using a phase separator cartridge and the resulting solution is evaporated under reduced pressure to furnish the title compound (105 mg, 63percent).10431] UPEC-MS (Method 2): R=1 .28 mm10432] MS (ESI pos): mlz=414 (M+H)
The synthetic route of 4-Fluoro-3-methylbenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Boehringer Ingelheim International GmbH; GIOVANNINI, Riccardo; CUI, Yunhai; DOODS, Henri; FERRARA, Marco; JUST, Stefan; KUELZER, Raimund; LINGARD, Iain; MAZZAFERRO, Rocco; RUDOLF, Klaus; US2014/343065; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts