Synthetic Route of 16532-79-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16532-79-9, name is 4-Bromophenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows.
(4-bromo-phenyl)-2,2-dimethyl-acetonitrile To a cooled (0 C.) solution of 4-bromo-phenyl-acetonitrile (7.0 g, 35.7 mmol) in THF (70 mL) was added methyl iodide (4.9 mL, 78.6 mmol) followed by KOBu-t (79 mL, 1 M in THF). On complete addition, the cold bath was removed and stirring continued for a further 1 hr. The reaction mixture was then diluted with ether, washed sequentially with water and brine, dried over MgSO4 and concentrated. The residue was purified by flash chromatography (eluding with 10% ethyl acetate in hexanes) to give 7.49 g of the title compound as an oil. 1H NMR (CDCl3) d 1.70 (s, 6H), 7.34 (d, J=8 Hz, 2H), 7.50 (d, J=8 Hz, 2H). MS (EI) m/z 223, 225 Br pattern (M)+
The chemical industry reduces the impact on the environment during synthesis 4-Bromophenylacetonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Burns, Christopher J.; Dankulich, William P.; McGarry, Daniel G.; Volz, Francis A.; US2002/193410; (2002); A1;,
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