Continuously updated synthesis method about 4-(tert-Butyl)phthalonitrile

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32703-80-3, name is 4-(tert-Butyl)phthalonitrile, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks

Example 7 Z1XXX (tBu)10.0 parts of 4-tert-butylphthalonitrile (manufactured by Tokyo Chemical Industry Co., Ltd.) and 84 parts of methanol were mixed. A mixture of 8.15 parts of a 28% sodium methoxide methanol solution (manufactured by Wako Pure Chemical Industries, Ltd.) and 73 parts of methanol was added dropwise to the resulting mixture while keeping the temperature at 5 for 1 hour. The resulting mixture was stirred at 5 to 20 for 2 days.5.42 parts of acetic acid and 6.14 parts of ethyl cyanoacetate (manufactured by Tokyo Chemical Industry Co., Ltd.) were added to the resulting mixture at 10 to 20 . The obtained mixture was stirred at 65 for 3 days.To the resulting mixture was added 2.69 parts of acetic acid and 3.07 parts of ethyl cyanoacetate (manufactured by Tokyo Chemical Industry Co., Ltd.), followed by stirring at 65 C for 3 days. To the obtained mixture, 5.36 parts of acetic acid, 7.25 parts of barbituric acid (manufactured by Tokyo Chemical Industry Co., Ltd.) and 363 parts of water were added, and the mixture was stirred at 65 C for 9 days.The obtained mixture was subjected to solvent distillation using a rotary evaporator, and the obtained residue was purified by column chromatography to obtain a mixture of a compound represented by the formula IZ1-20 and a compound represented by the formula IZ1-21.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Seumittomo Gaga Kku Gabu Siki Ga I Sya; O Da-ga-cheu-na-ri; Do Ga-i-ma-na-bu; Ha Ma-ki-hi-ro-hu-mi; (366 pag.)KR2018/26347; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts