Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2941-29-9, name is Cyclopentanone-2-carbonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 2941-29-9
ntermediate 7f: Benzyl N-[4-[(2-cyanocyclopenten-1 -yI)-(cyanomethyl)amino]-2- fluoro-phenyl]carbamate[00242] A mixture of benzyl N-[4-(cyanomethylamino)-2-fluoro-phenyl]carbamate (4.43g, 14.7gmmol), 2-oxocyclopentanecarbonitrile (1 .62g, 14.81 mmol) and p-toluenesulfonic acidmonohydrate (0.25g, 1 .47mmol) in toluene (25mL) was heated to 150 °C with under Dean Stark conditions for 3 hours. Additional 2-oxocyclopentanecarbonitrile (1.65g, 15.l6mmol) was added and the reaction was stirred for 2 hours left at 150 °C under Dean-Stark conditions. The reaction was then cooled to room temperature and concentrated in vacuo to afford a brown oil. The brown oil was partitioned between sat. aq. NaHCO3 (5OmL) and EtOAc (5OmL). The aqueous layer was thenextracted with EtOAc (2 x 5OmL), washed with brine (3 x 5OmL), dried over Na2504, filtered and concentrated in vacuo to afford benzyl N-[4-[(2-cyanocyclopenten-1 -yl)-(cyanomethyl)amino]-2- fluoro-phenyl]carbamate as a brown oil (8.34g, 13.46mmol, 91percent yield).1H NMR (DMSO-d6, 400MHz) O/ppm: 9.64 (1H, 5), 7.77 (1H, t, J = 8.8Hz), 7.13-7.45 (7H, m), 5.17 (2H, 5), 4.84 (2H, 5), 2.59-2.63 (2H, m), 2.50-2.55 (2H, m), 1.83-1.91 (2H, m).MS Method 2: RT: 1.79 mi mlz 391.3 [M+H]
The synthetic route of 2941-29-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; REDX PHARMA PLC; ARMER, Richard; BELFIELD, Andrew; BINGHAM, Matilda; JOHNSON, Alice; MARGATHE, Jean-Francois; AVERY, Craig; HUGHES, Shaun; MORRISON, Angus; (278 pag.)WO2016/51193; (2016); A1;,
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