Reference of 2032-34-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2032-34-0, name is 3,3-Diethoxypropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 16 Ethyl 2-[(2-cyanovinyl)amino]-4-ethoxy-5-acetylamidobenzoate (a compound of formula I, R=ethyl) To a mixture of trifluoroacetic acid (60 mL) and water (10 mL) at room temperature, 2-cyanoacetaldehyde diethylacetal (20 mL, 0.133 mol, commercially available) was added, and reacted for 9 h at room temperature to obtain a solution 1. In addition, the title compound of example 15 (26 g, 0.1 mol) was suspended in ethyl acetate (400 mL) at room temperature, followed by addition of the above obtained solution 1. The reaction mixture first became clear and then changed to cloudy. After stirring for 12 h at room temperature, the reaction mixture was filtered and washed with ethyl acetate and dried to give 28 g of the title compound as a gray white powder with a yield of 90.6%. 1HNMR (300 MHz, DMSO) delta 1.30 (t, 3H), 1.39 (t, 3H), 2.06 (s, 3H), 4.22 (q, 2H), 4.29 (q, 2H), 5.13 (d, 1H), 7.04 (s, 1H), 8.20 (t, 1H), 8.36 (s, 1H), 9.01 (s, 1H), 10.45 (d, 1H). MS/ESI: 316.0 (M-H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,3-Diethoxypropanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Topharman Shangai Co., Ltd.; US2011/263860; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts