Adding a certain compound to certain chemical reactions, such as: 17417-09-3, name is 2-Fluoro-5-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17417-09-3, SDS of cas: 17417-09-3
To a solution of 3-cyano-4-fluoronitrobenzene (0.530 g, 3.19 mmol) and N- (2-fluoro-5-hydroxyphenyl) -2- [3- (trifluoromethyl) phenyl] acetamide (1.00 g, 3.19 mmol) in N, N- dimethylformamide (5 mL) was added potassium carbonate (0.530 g, 3.83 mmol), and the mixture was stirred at room temperature for 4 hr. The reaction mixture was diluted with ethyl acetate (100 mL) , washed successively with water (100 mL) and saturated brine (100 mL) , and dried over anhydrous magnesium sulfate. Insoluble material was filtered off. The obtained organic layer was purified by basic silica gel column chromatography (eluate: 50% ethyl acetate/n-hexane) , and the obtained solution was concentrated under reduced pressure to give the title compound (1.38 g, 94%) as a yellow oil. 1H-NMR (DMSO-d6, 300 MHz) delta 3.91 (2H, s) , 7.01 (IH, d, J = 9.3 Hz), 7.08 – 7.16 (IH, m) , 7.48 (IH, dd, J = 10.7, 9.0 Hz), 7.52 – 7.66 (3H, m) , 7.70 (IH, s) , 7.98 (IH, dd, J = 6.6, 3.0 Hz), 8.39 – 8.44 (IH, m) , 8.84 (IH, d, J = 2.7 Hz), 10.31 (IH, s) .
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Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; OKANIWA, Masanori; TAKAGI, Terufumi; WO2010/64722; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts