Related Products of 120315-65-3, A common heterocyclic compound, 120315-65-3, name is 4-Bromo-3-methoxybenzonitrile, molecular formula is C8H6BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 4-bromo-3-methoxy~benzonitrile (400mg, 1.88mmol), 5-(4,4,5,5-tetramethyl- p ,3.2Jdioxaborotan-2-yl)«py?dine-3-carbaldehyde (440 mg, 1.88 mmol), PdCl2(PPh3)Z (108mg, 0.15mmol) and Na2CO3 (2M in water, 1.88mL, 3.77mmol) in 1,4-dioxanbeta (8 mL) was heated at 100C for 1.5h. After concentration in vacuo, the resulting residue was purified by flash column to give the title compound (449 mg, 100%) as white solid; ESI- MS mlr. 239 IM+1)*.
The synthetic route of 120315-65-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; CHAMOIN, Sylvie; HU, Qi-Ying; PAPILLON, Julien; WO2010/130796; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts