Reference of 19295-57-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19295-57-9, name is 3-Hydroxy-2,2-dimethylpropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 3-hydroxy-2,2-dimethylpropanenitrile (4 g, 40.35 mmol) and CBr4(20.7 g, 62.4 mmol) in anhydrous THF (100 mL) was added a solution of triphenylphosphane(12.7 g, 48.4 mmol) in anhydrous THF (100mL) at 0 C. The reaction mixture was stirred at rtovernight, then the mixture was concentrated in vacuo and the residue was purified by silica gelcolumn chromatography (PE/EtOAc (v/v) = 20/1 ) to give the title product as yellow oil (3.27 g,yield 50.0%). 1HNMR (400 MHz, CDCh) 8 (ppm): 3.40 (s, 2H), 1.47 (s, 6H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Hydroxy-2,2-dimethylpropanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts