Application of 17216-62-5, The chemical industry reduces the impact on the environment during synthesis 17216-62-5, name is Diethyl 2-(2-cyanoethyl)malonate, I believe this compound will play a more active role in future production and life.
(a) 2-(2-Cyanoethyl)malonic acid diethylester (40 g) was reacted with sodium hydride (4.4 gm) in tetrahydrofuran at 20 C. 2-Chloro-5-methyl-3-nitro-pyridine (35 g) was added and the internal temperature was raised to 100 C. (some tetrahydrofuran distilled off) over 4.25 hrs. The reaction mixture was partitioned between chloroform and water and treated with charcoal. Vacuum distillation of the chloroform extract and then chromatography (CHCl3, silica column) of the distillation residues gave 4-(5-methyl-3-nitropyrid-2-yl)-4,4-bis (carbethoxy)-butyronitrile (24.5 g) as a yellow solid m.p. 48-49 C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diethyl 2-(2-cyanoethyl)malonate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Smith Kline & French Laboratories Limited; US4444772; (1984); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts