Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5414-21-1, name is 5-Bromovaleronitrile, A new synthetic method of this compound is introduced below., SDS of cas: 5414-21-1
General procedure: A stainless steel autoclave was charged with glycerol (1 mmol), base B (6 mmol), and NMP (1mL), flushed three times with CO2, and finally charged with CO2 to 0.7 MPa at room temperature.The obtained mixture was magnetically stirred at 25 C for 1 h, and an alkyl halide (10 mmol) wasadded at room temperature after CO2 evacuation, followed by repeated CO2 flushing/charging to 0.7MPa. The reaction mixture was magnetically stirred at 25 C for 18 h under 0.7 MPa pressure ofCO2. After EtOAc was added to the resulting mixture to precipitate the dissolved salt, the salt wasremoved using a Buchner funnel and washed with EtOAc. The combined filtrate was concentrated in vacuo, and the obtained product ratios were determined by 1H NMR measurements. The crudeproduct was purified by silica gel column chromatography, affording linear tricarbonates 1.Compounds 1g, 1h, and 1k were further purified by gel permeation liquid chromatography.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Mihara, Masatoshi; Moroga, Kaname; Iwasawa, Tetsuo; Nakai, Takeo; Ito, Takatoshi; Ohno, Toshinobu; Mizuno, Takumi; Synlett; vol. 29; 13; (2018); p. 1759 – 1764;,
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