Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77326-36-4, name is 2-Amino-6-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H5FN2
To a solution of 3-hydroxy-2,2-dimethyl-N-propy- lpropanamide (20.2 g, 0.127 mol) (Example 197d) in dry THF (500 mE) was carefully added NaH (60% in mineral oil, 7.64 g, 0.191 mol) in small portions at 0C. under nitrogen. The reaction mixture was then warmed to room temperature and stirred under nitrogen for 1 hr. To this solution was slowly added at room temperature 2-amino-6-fluorobenzo-nitrile (17.3 g, 0.127 mol) in THF (100 mE) and the reaction mixture refluxed overnight under nitrogen then cooled down to room temperature, quenched with brine, and extracted with EtOAc (3x). The combined organic layers were washed with brine, dried over Na2SO4, evaporated and the residue was crystallized from EtOAc/Hexane to give the compound as a white solid (16.5 g, 48%). MS 276 (MHj.
According to the analysis of related databases, 77326-36-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SENOMYX, INC.; Tachdjian, Catherine; Karanewsky, Donald; Tang, Xiao Qing; Liu, Hanghui; US2015/245642; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts