Electric Literature of 4513-77-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4513-77-3, name is 2-Oxocyclohexanecarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 2-oxocyclohexanecarbonitrile (250 mg, 2.03 mmol) in EtOH (20 mL) was added CHCI3 (1 mL) and Pt02 (55.3 mg, 0.244 mmol) and the reaction mixture was stirred under hydrogen atmosphere (3 atm) for 67 h. Subsequently the reaction mixture was filtered over Celite and 4N HCI in dioxane was added to the filtrate, which was then concentrated to afford the title compound. The product was used in the next step without further purification.
The synthetic route of 2-Oxocyclohexanecarbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; ALTMANN, Eva; HOMMEL, Ulrich; LORTHIOIS, Edwige, Liliane, Jeanne; MAIBAUM, Juergen, Klaus; OSTERMANN, Nils; QUANCARD, Jean; RANDL, Stefan, Andreas; VULPETTI, Anna; WO2014/2054; (2014); A1;,
Nitrile – Wikipedia,
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