Electric Literature of 67832-11-5, These common heterocyclic compound, 67832-11-5, name is 4-Bromo-2-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 4-bromo-2-methylbenzonitrile (4.00 g, 20.4 mmol) in THF (40 mL) was added dropwise lithium diisopropylamide (2 Mm THF, 16 mL, 32 mmol) in THF (10 mL) over a period of 20 mm at -78 C under nitrogen atmosphere. After stirring 2 hr at the sametemperature, iodomethane (3.48 g, 24.5 mmol) was added dropwise over a period of 20 mm. The mixture was warmed to room temperature, stirred for 3 h, re-cooled to 0 C and acidified with 1 N hydrochloric acid. The aqueous layer was extracted with ethyl acetate three times. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by flash chromatography (0-10% ethyl acetate inpetroleum ether) to afford the title compound. LCMS [M+H] = 210.
The synthetic route of 67832-11-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BISWAS, Dipshikha; DING, Fa-Xiang; DONG, Shuzhi; GU, Xin; JIANG, Jinlong; PASTERNAK, Alexander; SUZUKI, Takao; VACCA, Joseph; XU, Shouning; WO2015/103756; (2015); A1;,
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