In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 53312-81-5 as follows. Safety of 5-Amino-2-fluorobenzonitrile
A solution of (R)-tert-butyl [1-(2-chloro-6-propylpyrimidin-4-yl)piperidin-3-yl](methyl)carbamate (50 mg, 0.14 mmol) prepared in Preparation 28 and 5-amino-2-fluorobenzonitrile (23 mg, 0.17 mmol) in n-butanol (1 ml) was refluxed under stirring overnight. The reaction mixture was cooled to room temperature and then concentrated under reduced pressure. The resulting residue was purified with silica gel column chromatography (n-hexane/ethyl acetate = 1/1 ? dichloromethane/methanol = 10/1) and then dissolved in methanol. Hydrogen chloride gas was added to the solution. The reaction mixture was stirred at room temperature for 5 hours and then filtered to give 23 mg of the product as a pale yellow solid.
According to the analysis of related databases, 53312-81-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; YUHAN CORPORATION; LEE, Hyun-Joo; KIM, Dong-Hoon; KIM, Tae-Kyun; YOON, Young-Ae; SIM, Jae-Young; CHA, Myung-Hun; JUNG, Eun-Jung; AHN, Kyoung-Kyu; LEE, Tai-Au; WO2012/115478; (2012); A2;,
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