These common heterocyclic compound, 906673-45-8, name is 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile
To a solution of 40g (0.13 mole) of 4-(4-bromo-3-(hydroxymethyl) phenoxy) benzonitrile (V) and 20.21 g (0.198 mol) of acetic anhydride in dichloromethane, two drops of pyridine was added, and the mixture was stirred at room temperature. After completion of reaction, the reaction mixture was quenched with water and extracted with dichloromethane. The organiclayer was separated, washed with saturated sodium bicarbonate solution 0. iN hydrochloric acid and water and dried over sodium sulphate. On filtration, the filtrate was evaporated to remove the solvent completely and yield 2-bromo-5-(4-cyanophenoxy) benzyl acetate (IV).Yield %: 97.0; Purity %: 98.0
The synthetic route of 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.; PULLAGURLA, Manik Reddy; PITTA, Bhaskar Reddy; NAMANA, Suresh Babu; RANGISETTY, Jagadeesh Babu; (21 pag.)WO2018/207216; (2018); A1;,
Nitrile – Wikipedia,
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