Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13531-48-1, name is Methyl 3-cyanobenzoate, A new synthetic method of this compound is introduced below., Product Details of 13531-48-1
EXAMPLE 24 3-(3,4,8,9-Tetrahydro-6-methoxy-3,3,8,8-tetramethylfuro[2,3-h]isoquinolin-1-yl)benzoic acid methyl ester Conc. sulfuric acid (1.8 mL) was added to a solution of methyl 3-cyanobenzoate (2.42 g, 15.0 mmol) in toluene (15 mL) and acetic acid (8 mL) with cooling in ice and then a solution of 2,3-dihydro-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)benzofuran (3.49 g, 15.0 mmol) in toluene (15 mL) was added to the mixture. The mixture was stirred at 80 C for 1 hour. The reaction mixture was cooled with ice, combined with an aqueous solution containing sodium acetate (6.69 g, 81.6 mmol), and then neutralized with conc. aqueous ammonia and extracted twice with ethyl acetate. The combined organic layer was washed with water and extracted with 1 M hydrochloric acid3 times. The combined aqueous layer was neutralized with cone. aqueous ammonia and extracted twice with ethyl acetate. The combined organic layer was washed with water and brine, dried over sodium sulfate, filtered, and concentrated under reduced pressure. The residue was subjected to a column chromatography on a basic silica gel (hexane/ethyl acetate 10:1) and crystallized from ethyl acetate-hexane to obtain the title compound (2.18 g, Yield: 37%). Melting point: 137-138 C. 1H NMR (CDCl3) delta 1.26 (6H, s), 1.30 (6H, s), 2.16 (2H, s), 2.70 (2H, s), 3.92 (3H, s), 3.93 (3H, s), 6.63 (1H, s), 7.48 (1H, t, J = 7.8 Hz), 7.62 (1H, dt, J = 7.8, 1.5 Hz), 8.05-8.12 (2H, m).
The synthetic route of 13531-48-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1270577; (2003); A1;,
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