Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Aminoprop-1-ene-1,1,3-tricarbonitrile
General procedure: mmol), malononitrile dimer (1.5 mmol), AcOH (1 mmol), piperidine(1 mmol), and EtOH (10 mL) were stirred at refluxing for1 h. After completion of the reaction (confirmed by TLC), thereaction mixture was filtered to afford the crude product, whichwas further washed with 95% EtOH to give pure product 4. Thestructures of the products were well characterized by NMR andHRMS studies. The characterization data of representative compound 4a. Compound 4a: light yellow solid; mp 300.9-302.0 C. 1H NMR(400 MHz, DMSO-d6): delta = 9.33 (s, 1 H), 7.37 (d, J = 7.6 Hz, 2 H),7.25 (d, J = 7.6 Hz, 2 H), 6.41 (s, 2 H), 6.24 (s, 2 H), 5.40 (s, 1 H),4.08 (t, 2 H), 3.89-3.73 (m, 2 H) ppm. 13C NMR (100 MHz,DMSO-d6): delta = 159.8, 154.2, 152.4, 149.1, 142.5, 130.9, 129.7,127.6, 116.6, 106.6, 92.6, 69.9, 44.4, 43.3, 36.6 ppm. ESI-HRMS:m/z calcd for C17H1435ClN7O2 [M – H]-: 382.0898; found:382.0811; calcd for C17H1437ClN7O2 [M – H]-: 384.0898; found:384.0771
The synthetic route of 868-54-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Sun, Feilong; Zhu, Fengjuan; Shao, Xusheng; Li, Zhong; Synlett; vol. 26; 16; (2015); p. 2306 – 2312;,
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