Some common heterocyclic compound, 939-80-0, name is 4-Chloro-3-nitrobenzonitrile, molecular formula is C7H3ClN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4-Chloro-3-nitrobenzonitrile
In dry acetonitrile (40 ml) were dissolved 4-chloro-3-nitrobenzonitrile (4.0 g, 21 .98 mmol), ethyl glycinate hydrochloride (4.6 g, 32.97 mmol) and diisopropyl ethylamine (10.9 ml, 65.94 mmol) in microwave vial and the mixture was irradiated at 125 C for 30 minutes. The solvent was removed under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate/hexane) to yield 4.0g (73.13%) of the title compound . 1 H- NMR(400MHz,CDCl3)delta: 1.33(t,J=7.2Hz,3H),4.13(d,J=5.2Hz,2H),4.32(q,J=7.2Hz,2H ),6.77 Eta),8.81 (5, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 939-80-0, its application will become more common.
Reference:
Patent; DAIICHI SANKYO COMPANY, LIMITED; KATOCH, Rita; INAGAKI, Hiroaki; FUJISAWA, Tetsunori; WO2014/24056; (2014); A1;,
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