Electric Literature of 3032-92-6,Some common heterocyclic compound, 3032-92-6, name is 4-Ethynylbenzonitrile, molecular formula is C9H5N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Polymer supported metal catalyst (25mg, 21×10-3mmol) in water (5mL) was taken in a 50mL round bottom flask. Then phenylacetylene (1mmol), sodium azide (1.2mmol) and benzyl bromide (1mmol) were added and stirred at room temperature for 180 min. After the completion of the reaction, the catalyst was filtered off and washed with water followed by acetone and dried in oven. The filtrate was extracted with ethyl acetate (3×20ml) and the combined organic layers were dried with anhydrous Na2SO4 by vacuum. All the prepared compounds were confirmed by 1H and 13C NMR.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Ethynylbenzonitrile, its application will become more common.
Reference:
Article; Molla, Rostam Ali; Roy, Anupam Singha; Ghosh, Kajari; Salam, Noor; Iqubal, Md Asif; Tuhina; Islam, Sk Manirul; Journal of Organometallic Chemistry; vol. 776; (2015); p. 170 – 179;,
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