Application of 115279-57-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
10210] 4,6-dichloro- 1 ,5-naphthyridine-3-carboxylate ethyl (5.9 g, 21.9 mmol) and 2-(4-aminophenyl)-2-methyl propanenitrile (3.5 g, 21.9 mmol) were dissolved in 100 mE tert-butanol. To the resulting mixture was added potassium carbonate (6.0 g, 43.8 mmol). The reaction mixture was heated to reflux and reacted for 15 hrs. The reaction was cooled to room temperature, and then concentrated in a reduced pressure. To the residue was added 100 mE water and 100 mE DCM. The phases were separated. The aqueous phase was extracted with 100 mE DCM. The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated. The resulting crude product is separated by silicagel column chromatography (EtOAc/PE=0-1/2) to obtain a pale yellow solid of 6-chloro-4-((4-(2-cyanopropan- 2-yl)phenyl)amino)-1 ,5-naphthyridine-3-carboxylate ethyl(6.9g).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Aminophenyl)-2-methylpropanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; XUANZHU PHARMA CO., LTD.; Wu, Frank; Shu, Chutian; US2015/239885; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts