Reference of 53312-81-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53312-81-5, name is 5-Amino-2-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of commercially available 5-amino-2-fluoro-benzonitrile (953 mg) in dry tetrahydrofurane (70 mL) were added benzyl chloroformate (1.20 mL) and potassium carbonate (1.16 g). The resulting suspension was stirred at room temperature for 16 h. Additional benzyl chloroformate (1.20 mL) and potassium carbonate (1.16 g) were added and stirring at room temperature was continued for 7 h. The mixture was diluted with ethyl acetate (70 mL), washed with water (2×70 mL), dried (MgSO4), filtered and concentrated. The remaining residue was purified by flash chromatography (silica, cyclohexane/ethyl acetate) to afford the title compound (1.47 g; 78%). [MH]+=271.
The chemical industry reduces the impact on the environment during synthesis 5-Amino-2-fluorobenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Alantos Pharmaceuticals, Inc.,; US2006/173183; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts