Synthetic Route of 6575-00-4, These common heterocyclic compound, 6575-00-4, name is 3,5-Dichlorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 40 (1.07 g, 5 mmol), 3,5-dichloro-benzonitrile (1.3 g, 7.56 mmol), K2CO3 (2.07 g, 15.0 mmol) and NMP (10 mL) was stirred and heated to 110° C. for 6 h. The reaction mixture was cooled to RT and diluted with H2O (50 mL) and twice extracted with EtOAc. The combined organic extracts were washed sequentially with water and brine, dried (Na2SO4), filtered and concentrated in vacuo. The crude product was purified by SiO2 chromatography eluting with EtOAc/hexane (10:90) to afford 0.328 g of 102a.
The synthetic route of 6575-00-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Roche Palo Alto LLC; US2005/239881; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts