Some common heterocyclic compound, 1000339-52-5, name is 3-Fluoro-2-nitrobenzonitrile, molecular formula is C7H3FN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks
Synthesis of 3-((3,4-dimethylphenyl)amino)-2-nitrobenzonitrile 3,4-Dimethylaniline (4.4 g, 36.1 mmol) was added into THF (60 mL). Sodium hydride (1.1 g, 45.2 mmol) was added and stirred for 1 hour. 3-Fluoro-2-nitrobenzonitrile (5 g, 30.1 mmol) was added and stirred for about 16 hours at room temperature. Water (2 mL) was added to quench the unreacted sodium hydride. The solvent was then evaporated and the residue was then purified by column chromatography using THF:hexane (1:4, v/v) as the eluent. 6.5 g (81% yield) of a red solid was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1000339-52-5, its application will become more common.
Reference:
Patent; Universal Display Corporation; KWONG, Raymond; LAM, Sze Kui; LAM, Siu Tung; TSANG, Kit Yee; LEE, Chi Hang; SZIGETHY, Geza; (159 pag.)US2016/218303; (2016); A1;,
Nitrile – Wikipedia,
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