Adding a certain compound to certain chemical reactions, such as: 261951-81-9, name is 3-Fluoro-2-(trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 261951-81-9, HPLC of Formula: C8H3F4N
The compound obtained in Step 3 of Comparative Example 8 (148mg), 3- fluoro-2- (trifluoromethyl) benzonitrile (100 mg), sodium carbonate (164 mg) was added to DMSO (2 mL), 15 hours at 120. C. It was allowed to react. After filtration the insoluble matter to afford the title compound by HPLC column chromatography by preparative reverse phase (18mg, 17% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Fluoro-2-(trifluoromethyl)benzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; TAIHO PHARMACEUTICAL COMPANY LIMITED; MINAMIGUCHI, KAZUHISA; OKAJIMA, SHIGEO; AOKI, SHINICHI; ASAI, MASANORI; ASAI, TAKAHIRO; YAMANAKA, HIROYOSHI; DOHI, SUGURU; (149 pag.)JP5851663; (2016); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts