Electric Literature of 766-84-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 766-84-7 name is 3-Chlorobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The appropriate quantity of stock solution A was added to a 4 mL vial containing the aryl chloride (1.00 mmol) and NaOtBu (230 mg, 2.40 mmol), unless otherwise stated, in 1.5 mL of DME. The thiol (1.00 mmol) was then added, and the vial sealed with a cap containing a PTFE septum. The mixture was heated at 110 0C until the chloroarene was consumed, as determined by GC. Silica gel (0.5 g) was added, and the solvents were evaporated under reduced pressure. The crude residue was purified by column chromatography on silica gel using hexane or mixtures of hexane and ethyl acetate as eluent. Aryl sulfides were isolated in the yields reported in Tables 5 and 6.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chlorobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; YALE UNIVERSITY; WO2007/64869; (2007); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts