Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6621-59-6, name is 6-Bromohexanenitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 6621-59-6
In a solution of compound MI (2 g; 4,767 mmol) and N, N-diisopropylethylamine (8,10 ml; 47,67 mmol) in acetonitrile (80 ml) 6-bromohexanenitrile (6,32 ml ; 47,67 mmol) was added. Reaction mixture was stirred at 80C for 21 hours. After evaporation of the solvent, mixture was diluted with dichlormethane and water. The organic layer was dried over NA2SO4. The solvent was then evaporated under reduced pressure and the compound was purified on a silica gel column, eluent CH2Cl2 : MeOH: NH40H = 90: 9: 1.5. 532 mg of the compound 19 was obtained. MS (m/z) : 515,70 [MH] +. IR (CM~L)/KBR : 3444,2973, 2937,2875, 2247 (C_N), 1712, 1637,1459, 1375,1352, 1307,1265, 1179,1139, 1090,1052, 1004,958, 901,860, 810,773, 750,705, 670. The macrolide 19 (532 mg; 1.034 mmole) was dissolved in 25 mL of absolute ethanol and HYDROGENATED in a reactor with the catalyst PTOZ (53 mg) under pressure of 40 atm of H2 for 24 hours. The reaction mixture was filtered and the solvent was evaporated under reduced pressure. 463 mg of the mixture was obtained. The mixture was purified on a silica gel column, eluent CH2CI2 : MeOH: NH40H=6: 1: 0.1 ; 180 mg of amine 21 was obtained. MS (M/Z) : 519.74 [MH] +. Indomethacin D10 (62 mg; 0.174 mmole) was dissolved in 10 mL of dry dichloromethane. Triethylamine (0.189 mL), 47 mg of 1-hydroxybenzotriazole, the compound 21 (90 mg; 0.174 mmole) and 1- (3-DIMETHYLAMINOPROPYL)-3-ETHYL- carbodiimide hydrochloride (133 mg) were added. The reaction mixture was stirred in an inert atmosphere at room temperature for 24 h. The solvent was then evaporated under reduced pressure and the compound was purified on a silica gel column in the solvent system CH2Cl2 : MeOH: NH40H = 90: 8: 1.105 mg of compound 22 was obtained; MS (M/Z) : 858. 81 [MH] +.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PLIVA PHARMACEUTICAL INDUSTRY, INC.; WO2004/94449; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts