In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26391-06-0, name is 2-Cyano-N,N-diethylacetamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C7H12N2O
To a mixture of tert-butyl 7-formyl-3,4-dihydroisoquinoline-2(lH)-carboxylate (1 g, 3.83 mmol), 2-cyano-N,N-diethylacetamide (536 mg, 3.83 mmol) and ammonium acetate (1.47 g, 19.13 mmol) in methanol (10 mL) was stirred at reflux for 2 h. After cooling to rt, the mixture was concentrated to dryness. The residue was diluted with EtOAc (40 mL), washed with water (40 mL), followed by brine (40 mL). The organic layer was dried over Na2S04 and concentrated. The crude residue was purified by silica gel chromatography to afford 800 mg of tert-butyl 7-(2-cyano-3-(diethylamino)-3-oxoprop-l-en-l- yl)-3,4-dihydroisoquinoline-2(lH)-carboxylate as a yellow gum.
The synthetic route of 26391-06-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PRINCIPIA BIOPHARMA INC.; LOU, Yan; OWENS, Timothy Duncan; BRAMELD, Kenneth Albert; GOLDSTEIN, David Michael; (171 pag.)WO2019/99576; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts