Related Products of 2469-99-0, The chemical industry reduces the impact on the environment during synthesis 2469-99-0, name is 3-Oxobutanenitrile, I believe this compound will play a more active role in future production and life.
General procedure: 3-Acetyl-2-aminothiophene Derivatives; General Procedure Carbonyl compound (0.025 mol) was added to freshly prepared cya-noacetone (0.03 mol) in either MeOH or EtOH (40 mL). Sublimed sul-fur S8 (0.03 mol) and piperidine (0.03 mol) were added and the mix-ture was stirred and heated to 55-65 C for 24 h. Ice was then addedand the formed precipitate was filtered under vacuum and washedwith water. The obtained solid was crystallised from a suitable sol-vent, with the exception of 4g and 4j, which were collected directlywithout further purification. 1-(2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)ethan-one (4a)Yield: 2.7 g (61%); brown solid; mp 230 C (toluene). 1H NMR (400 MHz, CDCl3): delta = 6.82 (s, 2 H), 2.92-2.87 (m, 2 H), 2.78-2.72 (m, 2 H), 2.44-2.38 (m, 2 H), 2.38 (s, 3 H).13C NMR (100 MHz, CDCl3): delta = 193.7, 168.6, 141.0, 121.3, 112.2,31.74, 29.1, 28.7, 27.3.HRMS (ESI): m/z calcd for [C9H11NOS + Na]+: 204.0454; found:204.0464.Anal. Calcd for C9H11NOS: C, 59.64; H, 6.12; N, 7.73; S, 17.69. Found: C,60.14; H, 6.10, N, 7.48; S, 17.25.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Oxobutanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Abdelwahab, Ahmed B.; Hanna, Atef G.; Kirsch, Gilbert; Synthesis; vol. 48; 17; (2016); p. 2881 – 2888;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts