51632-29-2, name is 2-(3-Phenoxyphenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 51632-29-2
3-phenoxyphenylacetonitrile was added to a 25 ml Schlenk reaction tube under a nitrogen atmosphere.(0.4 mmol), deuterated dimethylamine borane complex (4 equivalents), potassium t-butoxide (2.5 equivalents), deuterated N,N-dimethylformamide (5 ml), added to the reaction tube After the rubber stopper was placed in an oil bath, the reaction was carried out at 100 C for 18 h, and the end point of the reaction was determined by thin layer chromatography (TLC). After the reaction was completed, ethyl acetate was extracted and separated by column chromatography. The eluent was petroleum ether/acetic acid B. Ester (v:v=10:1),Obtaining alpha-tridemethyl-3-phenoxybenzenepropionitrile;Then, under a nitrogen atmosphere, a 25-ml two-neck round bottom flask was charged with alpha-tridemethyl-3-phenoxyphenylpropionitrile (0.2 mmol), sodium hydroxide (1.5 mmol/ml), water (8 ml). Ethanol (2ml) in round bottomThe flask was placed in a rubber bath and placed in an oil bath. The reaction was refluxed at 110 C for 5 h. The end point of the reaction was determined by thin layer chromatography (TLC). After the reaction was completed, ethyl acetate was extracted and separated by column chromatography. Petroleum ether / ethyl acetate (v: v = 5: 1) gave alpha-tridemethyl-3-phenoxyphenylpropionic acid, alpha-tridemethyl-fenofol.Product yield 70%, light yellow solid
The synthetic route of 51632-29-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; University of Science and Technology of China; Wang Yifeng; Xia Huimin; Zhang Fenglian; (10 pag.)CN108003004; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts