Application of 3215-64-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3215-64-3 as follows.
Step 22-Cyano-(2,6-dichlorophenyl)-acetic acid methyl ester: A 500 mL round-bottom flask was charged with absolute methanol (100 mL) and sodium (6.2 g, 269.57 mmol). After all of sodium was dissolved, the mixture was evaporated to dryness. Then, 30 mL tolune was added and the mixture was dried down again by evaperation to give fresh NaOMe. To this was added dimethyl carbonate (300 mL) and 2-(2,6- dichlorophenyl)acetonitrile (25 g, 134.41 mmol). The resulting solution was allowed to reflux for 2 hours. The reaction progress was monitored by TLC (AcOEt: PE=I :4). The mixture was quenched by the addition of of 100 mL ice H2O. Then, the pH was adjusted to ca. 6 by the addition of AcOH . The resulting mixture was then extracted with EtOAc (3 x 100 ml). Combined organic layers were then concentrated down in vacuo to afford a residue that was purified by a column chromatography eluted with a 20:1 PE / AcOEt. This resulted in 27.8 g (85%) of methyl 2-cyano-2-(2,6-dichlorophenyl)acetate as a white solid. This was used for next step without further purification.
According to the analysis of related databases, 3215-64-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KALYPSYS, INC.; WO2007/15866; (2007); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts