Electric Literature of 10406-25-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10406-25-4 as follows.
(S) -l- (2-bromopyridin-4-yl) piperidine-3-carboxylic acid (4a) (290 mg, 1.02 mmol)Was dissolved in 8 mL of anhydrous DMF,Was added to CDI (198 mg, 1.23 mmol) under nitrogen,Heated to 50 C for 21 h,Cooled to room temperature, 4-cyanobenzylamine (202 mg, 1.53 mmol) was added,Continue to nitrogen protection, heating to 50 reaction 24h,After cooling to room temperature, quenched with 1M HClThe reaction was carried out by adding 50 mL of water and extracting three times with dichloromethane. The combined organic phases were dried over anhydrous sodium sulfate and subjected to gradient gradient chromatographyThe column (ethyl acetate / petroleum ether = 5% to 100%) gave 289 mg of a white solid in 71% yield.
According to the analysis of related databases, 10406-25-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Southern Medical University; Li Zhonghuang; Wang Guangfa; Wu Xiaoyun; Tian Yuanxin; Wan Shanhe; Zhang Tingting; Hu Xiang; Hou Ju; Long Lifan; Liu Siming; Zhu Zhengguang; Zhang Jiajie; (22 pag.)CN107089968; (2017); A;,
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