Some common heterocyclic compound, 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, molecular formula is C12H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile
To a solution of 7-bromo-benzo[1 ,2,5]thiadiazole-4-carbaldehyde (2.0 g, 8.2 mmol) in anhydrous chloroform (875 cm3) is added pyridine (46.5 cm3, 576 mmol). The mixture is then degassed with nitrogen before 3- (dicyanomethylidene) indan-1 -one (4.0 g, 21 mmol) is added. The solution is then further degassed and stirred for 20 minutes. The mixture is stirred at 40 C for 17 hours. The solid collected by filtration and washed with acetone (200 cm3), water (200 cm3), diethyl ether (200 cm3) and dichloromethane (200 cm3) to give intermediate 29 (3.0 g, 86%) as a pale yellow solid with very limited solubility.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1080-74-6, its application will become more common.
Reference:
Patent; MERCK PATENT GMBH; MORSE, Graham; NANSON, Lana; MITCHELL, William; KROMPIEC, Michal; D’LAVARI, Mansoor; PRON, Agnieszka; (327 pag.)WO2018/65350; (2018); A1;,
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