These common heterocyclic compound, 16532-79-9, name is 4-Bromophenylacetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 4-Bromophenylacetonitrile
To a solution of 5 g (0.025 mol)Of 4-bromobenzeneacetonitrile were added separately 6 · 47g (0.025mol)The iodine simple substance and40 ml of double distilled tetrahydrofuran,The reaction was dissolved and then cooled to _78 C, Slowly dropping the new system of 52ml of 2.4M sodium methoxide in methanol,Dropping to room temperature after the reaction 10h,Add distilled water to terminate the reaction;With 1M hydrochloric acid to neutral,Extraction with dichloromethane,Washed with saturated saline three times,Drying over anhydrous magnesium sulfate, filtration, rotary evaporation and column chromatography gave 3,4-bis (4-bromophenyl) maleimide in 78% yield.
The synthetic route of 4-Bromophenylacetonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fujian Normal University; Lin Zhenghuan; Ling Qidan; Wang Jingwei; Zheng Rong; Chen Huan; (12 pag.)CN107522646; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts